Pub. Date : 1989 May
PMID : 2539976
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1 alpha exerts glucose-dependent stimulatory and inhibitory effects on islet cell phosphoinositide hydrolysis and insulin secretion. | Glucose | interleukin 1 alpha | Homo sapiens |
| 2 | 1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose. | Glucose | interleukin 1 alpha | Homo sapiens |
| 3 | 2) Mannoheptulose, a competitive inhibitor of islet glucokinase, blocked the stimulatory effects of IL-1 noted in the presence of 7 mM glucose. | Glucose | interleukin 1 alpha | Homo sapiens |
| 4 | 6) These inhibitory effects of IL-1 were abolished if mannoheptulose was included during the 2-h incubation with 7 mM glucose plus 5.0 nM <protein-id="3605">IL-1. | Glucose | interleukin 1 alpha | Homo sapiens |
| 5 | 7</protein-id>) The diacylglycerol kinase inhibitor 1-monooleoylglycerol (100 microM) significantly restored insulin output after IL-1 exposure (with 7 mM glucose). | Glucose | interleukin 1 alpha | Homo sapiens |
| 6 | 8) Similar to the results obtained with 7 mM glucose plus IL-1, incubation of islets with 8-10 mM glucose alone produced dose-dependent impairments of [3H]inositol efflux patterns and inositol phosphate accumulation. | Glucose | interleukin 1 alpha | Homo sapiens |
| 7 | These results demonstrate that IL-1 has glucose-dependent stimulatory and inhibitory effects on beta-cell function. | Glucose | interleukin 1 alpha | Homo sapiens |