Pub. Date : 1989 Jan 10
PMID : 2539864
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5"-O-(3-thiotriphosphate). | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL). | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL). | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 4 | Thrombin-induced hydrolysis of PIP2 was inhibited by treatment of the membranes with pertussis toxin or pretreatment of intact platelets with 12-O-tetradecanoyl-13-acetate (TPA) prior to preparation of membranes. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |