Title : Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.

Pub. Date : 2016 Feb

PMID : 25398514






1 Functional Relationships(s)
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1 Bypass of the need for metabolic activation by treating cells with the corresponding reactive PAH-diol-epoxide metabolites resulted in similar adduct levels in all cell lines, which confirms that the influence of p53 is on the metabolism of the parent PAHs. Epoxy Compounds tumor protein p53 Homo sapiens