Pub. Date : 1989 Apr 1
PMID : 2539818
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of alpha-1-acid glycoprotein administration on propranolol binding and beta blockade in rats. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 2 | Alpha-1-acid glycoprotein (AAG), 750 mg/kg, was administered to rats to determine its effect on propranolol binding and beta blockade. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 3 | AAG treatment significantly increased the heart rate response to isoproterenol, compared to albumin (95.4 +/- 19.6 vs 28.3 +/- 16.7% of baseline value, measured 45 min after propranolol, P less than 0.001). | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 4 | AAG-treated rats had greater [3H]propranolol binding in serum (93.0 +/- 3.2 vs 76.7 +/- 3.0%, P less than 0.01) and a lower calculated unbound [3H]propranolol concentration in serum (2.7 +/- 1.3 vs 7.4 +/- 3.1 X 10(6) dpm/ml, P less than 0.001) than albumin-treated rats. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 5 | AAG-treated rats had greater [3H]propranolol binding in serum (93.0 +/- 3.2 vs 76.7 +/- 3.0%, P less than 0.01) and a lower calculated unbound [3H]propranolol concentration in serum (2.7 +/- 1.3 vs 7.4 +/- 3.1 X 10(6) dpm/ml, P less than 0.001) than albumin-treated rats. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 6 | These data demonstrate that AAG can alter propranolol pharmacokinetics and pharmacodynamics even when administered after the propranolol effect is evident. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 7 | These data demonstrate that AAG can alter propranolol pharmacokinetics and pharmacodynamics even when administered after the propranolol effect is evident. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 8 | Because the reported affinity of propranolol for cardiac beta receptors is 10,000 times greater than its affinity for AAG, these data suggest that AAG acted by altering propranolol disposition rather than by directly competing with beta receptors for drug. | Propranolol | orosomucoid 1 | Rattus norvegicus |
| 9 | Because the reported affinity of propranolol for cardiac beta receptors is 10,000 times greater than its affinity for AAG, these data suggest that AAG acted by altering propranolol disposition rather than by directly competing with beta receptors for drug. | Propranolol | orosomucoid 1 | Rattus norvegicus |