Pub. Date : 2015 Jun
PMID : 25395240
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 2 | Consistent with these findings, in this study, we reported that As2O3 inhibited hERG channel at both protein and mRNA levels and damaged hERG current but did not affect channel kinetics. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 3 | Consistent with these findings, in this study, we reported that As2O3 inhibited hERG channel at both protein and mRNA levels and damaged hERG current but did not affect channel kinetics. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 4 | Further, we demonstrated that As2O3 up-regulated miR-21 and miR-23a expression in hERG-HEK293 cells and neonatal cardiomyocytes. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 5 | In addition, knock-down of miR-21 by its specific antisense molecules AMO-21 was able to rescue Sp1 and hERG inhibition caused by As2O3. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 6 | This finding revealed that regulation of the NF-kappaB-miR-21-Sp1 signalling pathway is a novel mechanism for As2O3-induced hERG inhibition. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 7 | And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 8 | And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 9 | And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 10 | And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 11 | In brief, our study revealed that miR-21 and miR-23a are involved in As2O3-induced hERG deficiency at transcriptional and transportational levels. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 12 | This discovery may provide a novel mechanism of As2O3-induced hERG channel deficiency, and these miRNAs may serve as potential therapeutic targets for the handling of As2O3 cardiotoxicity. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 13 | This discovery may provide a novel mechanism of As2O3-induced hERG channel deficiency, and these miRNAs may serve as potential therapeutic targets for the handling of As2O3 cardiotoxicity. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |