Pub. Date : 1989 Apr
PMID : 2539480
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The beta-adrenergic antagonist propranolol binds stereoselectively both at 5-HT1A and 5-HT1B sites (with a several-fold selectivity for the latter) and, whereas it is a 5-HT1A antagonist, it appears to be a 5-HT1B agonist. | Propranolol | 5-hydroxytryptamine receptor 1B | Homo sapiens |
| 2 | The purpose of the present study was to modify the structure of propranolol in such a manner so as to reduce its affinity for 5-HT1B and beta-adrenergic sites while, at the same time, retaining its affinity for 5-HT1A sites. | Propranolol | 5-hydroxytryptamine receptor 1B | Homo sapiens |
| 3 | Removal of the side-chain hydroxyl group of propranolol, and conversion of its secondary amine to a tertiary amine, reduced affinity for 5-HT1B and beta-adrenergic sites. | Propranolol | 5-hydroxytryptamine receptor 1B | Homo sapiens |