Pub. Date : 2014
PMID : 25393427
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Ethanol treatment specifically inhibited the activation of the ERK but not JNK nor the p38 MAP signaling pathway. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Upon evaluating the effects of the inhibitors of these two signaling pathways, we determined that the Erk inhibitor replicated the effects of ethanol on the hepatocyte differentiation and attenuated the WNT/beta-catenin signaling, however, inhibitors of WNT only partially replicated the effects of ethanol on the hepatocyte differentiation. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Upon evaluating the effects of the inhibitors of these two signaling pathways, we determined that the Erk inhibitor replicated the effects of ethanol on the hepatocyte differentiation and attenuated the WNT/beta-catenin signaling, however, inhibitors of WNT only partially replicated the effects of ethanol on the hepatocyte differentiation. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | CONCLUSION: Our results demonstrated that ethanol negatively regulated hepatic differentiation of hESC-derived hepatic progenitors through inhibiting the MAPK/ERK signaling pathway, and subsequently attenuating the WNT signaling pathway. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | CONCLUSION: Our results demonstrated that ethanol negatively regulated hepatic differentiation of hESC-derived hepatic progenitors through inhibiting the MAPK/ERK signaling pathway, and subsequently attenuating the WNT signaling pathway. | Ethanol | mitogen-activated protein kinase 1 | Homo sapiens |