Pub. Date : 1989 Mar 1
PMID : 2538549
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. | Zidovudine | colony stimulating factor 2 | Homo sapiens |
| 2 | Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. | Zidovudine | colony stimulating factor 2 | Homo sapiens |
| 3 | Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. | Zidovudine | colony stimulating factor 2 | Homo sapiens |
| 4 | Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. | Zidovudine | colony stimulating factor 2 | Homo sapiens |
| 5 | Taken together, these findings suggest that GM-CSF increases HIV-1 replication in M/M, while at the same time enhancing the anti-HIV activity of AZT and related congeners in these cells. | Zidovudine | colony stimulating factor 2 | Homo sapiens |