Title : Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

Pub. Date : 1989 Mar 1

PMID : 2538549






5 Functional Relationships(s)
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1 Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. Zidovudine colony stimulating factor 2 Homo sapiens
2 Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. Zidovudine colony stimulating factor 2 Homo sapiens
3 Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. Zidovudine colony stimulating factor 2 Homo sapiens
4 Even in the face of this increased infection, GM-CSF also enhanced the net anti-HIV activity of 3"-azido-2"3"-dideoxythymidine (AZT) and several related congeners: 2"3"-dideoxythymidine (ddT), 2"3"-dideoxy-2"3"-didehydrothymidine (D4T), and 3"-azido-2"3"-dideoxyuridine (AZddU). Inhibition of viral replication in GM-CSF-exposed M/M was achieved with concentrations of AZT and related drugs, which were 10-100 times lower than those inhibitory for HIV-1 in monocytes in the absence of GM-CSF. Zidovudine colony stimulating factor 2 Homo sapiens
5 Taken together, these findings suggest that GM-CSF increases HIV-1 replication in M/M, while at the same time enhancing the anti-HIV activity of AZT and related congeners in these cells. Zidovudine colony stimulating factor 2 Homo sapiens