Title : Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.

Pub. Date : 2015 Jun

PMID : 25382218






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1 The new approach was thoroughly validated for the CYP3A4-mediated N-demethylation pathway of ketamine and applied to the determination of its kinetic parameters and the inhibition characteristics in presence of ketoconazole and dexmedetomidine. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens