Title : Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.

Pub. Date : 2015 Feb

PMID : 25381637






1 Functional Relationships(s)
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1 We speculated that the key factor might be the coenzyme pyridoxal 5"-phosphate (PLP), an active form of vitamin B6 (VB6), because media used in cell-based assays usually contain an excess amount of VB6 which leads to the activation of SPL. Vitamin B 6 pyridoxal phosphatase Homo sapiens