Title : Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.

Pub. Date : 2014 Oct

PMID : 25379021






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Selumetinib inhibited phosphorylation of ERK1/2 and RSK and had no effect on AKT phosphorylation in both sensitive and resistant cells. AZD 6244 mitogen-activated protein kinase 3 Homo sapiens