Pub. Date : 2015 Jan 1
PMID : 25377918
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vasopressin signaling is critical for the regulation of urea transport in the inner medullary collecting duct (IMCD). | Urea | arginine vasopressin | Rattus norvegicus |
| 2 | Increased urea permeability is driven by a vasopressin-mediated elevation of cAMP that results in the direct phosphorylation of urea transporter (UT)-A1. | Urea | arginine vasopressin | Rattus norvegicus |
| 3 | The identification of cAMP-sensitive phosphorylation sites, Ser(486) and Ser(499), in the rat UT-A1 sequence was the first step in understanding the mechanism of vasopressin action on the phosphorylation-dependent modulation of urea transport. | Urea | arginine vasopressin | Rattus norvegicus |
| 4 | These results elucidate the multisite phosphorylation of UT-A1 in response to cAMP, thus providing the beginning of understanding the intracellular factors underlying vasopressin stimulation of urea transport in the IMCD. | Urea | arginine vasopressin | Rattus norvegicus |