Title : Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade.

Pub. Date : 1989 Jan 17

PMID : 2537741






1 Functional Relationships(s)
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1 Cyclic nucleotide-elevating vasodilators stimulated cAMP- or cGMP-dependent protein phosphorylation, inhibited the activation of both protein kinase C and myosin light chain kinase, and inhibited the thrombin-induced hydrolysis of phosphatidylinositol-4,5-bisphosphate without affecting its resynthesis. Phosphatidylinositol 4,5-Diphosphate coagulation factor II, thrombin Homo sapiens