Title : A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4.

Pub. Date : 2014 Nov 6

PMID : 25375376






1 Functional Relationships(s)
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1 We found that a short-term (5 h) inhibition of ETC complex III with myxothiazol results in the phosphorylation of translation initiation factor eIF2alpha and upregulation of mRNA for the activating transcription factor 4 (ATF4) and several ATF4-regulated genes. myxothiazol eukaryotic translation initiation factor 2A Homo sapiens