Title : MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors.

Pub. Date : 2014 Nov 30

PMID : 25375091






2 Functional Relationships(s)
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1 MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors. Imatinib Mesylate mechanistic target of rapamycin kinase Homo sapiens
2 Herein, we showed rapamycin, a MTOR inhibitor and autophagy inducer, could reduce total and phospho-KIT expression levels and enhance apoptosis in imatinib-resistant GIST cells. Imatinib Mesylate mechanistic target of rapamycin kinase Homo sapiens