Pub. Date : 2014 Nov
PMID : 25374757
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-kappaB Pathways in Nasal Fibroblasts. | Histamine | interleukin 6 | Homo sapiens |
| 2 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 3 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 4 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 5 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 6 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 7 | PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. | Histamine | interleukin 6 | Homo sapiens |
| 8 | Here, we examined the role of histamine in IL-6 production and histamine receptor activity in nasal fibroblasts, along with the mechanisms underlying these effects. | Histamine | interleukin 6 | Homo sapiens |
| 9 | RESULTS: Elevated expression was seen for all histamine receptors, with IL-6 protein levels increasing significantly following histamine stimulation. | Histamine | interleukin 6 | Homo sapiens |
| 10 | Among the histamine-receptor specific antagonists, only the H1R antagonist significantly decreased IL-6 production in histamine-stimulated nasal fibroblasts. | Histamine | interleukin 6 | Homo sapiens |
| 11 | The p38 inhibitor strongly attenuated IL-6 production in histamine-stimulated nasal fibroblasts. | Histamine | interleukin 6 | Homo sapiens |
| 12 | CONCLUSIONS: The data presented here suggest that antihistamines may be involved in the regulation of cytokines, such as IL-6, due to the role of histamine as an inflammatory mediator in nasal fibroblasts. | Histamine | interleukin 6 | Homo sapiens |