Title : Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1.

Pub. Date : 2014 Dec

PMID : 25374129






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, piceatannol decreased TPA-induced expression of c-Fos and the DNA binding of AP-1. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
2 CONCLUSION: Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappaB and AP-1 via suppression of the IKKbeta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus