Title : Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.

Pub. Date : 2015 Jan

PMID : 25373357






1 Functional Relationships(s)
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1 EXPERT OPINION: The structural differences of the organophosphorus compounds (OP) and the available oximes reactivators of OP-inhibited AChE generate distinct toxicokinetic or PK profiles. organophosphorus acetylcholinesterase (Cartwright blood group) Homo sapiens