Title : Bradykinin analogs antagonize bradykinin-induced second messenger production in a sensory neuron cell line.

Pub. Date : 1989 Jan

PMID : 2536466






2 Functional Relationships(s)
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1 In these neuronal hybrids, we have found that bradykinin induces sequential elevation in the concentrations of several second messengers involved in neuronal activation, including inositol trisphosphate (6.5-fold), intracellular calcium (2.7-fold), and cyclic GMP (20.5-fold). Calcium kininogen 1 Homo sapiens
2 The same relative rank order of potency of inhibition of bradykinin-induced second messenger production was achieved in the inositol trisphosphate, calcium, and cyclic GMP assay systems, suggesting strongly that all three messenger systems are being activated by the same bradykinin receptor. Calcium kininogen 1 Homo sapiens