Pub. Date : 2015 Jan
PMID : 25352364
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Veratric acid suppressed the LPS-induced effects on the regulatory and catalytic subunits of phosphoinositide 3-kinase (PI3K), comprised of p85, p110alpha, p110beta and Akt. | veratric acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt. | veratric acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | In the measurement of histone acetylation levels, the LPS-stimulated acetylation of histone H4 was significantly attenuated by veratric acid, and was also reduced following the inhibition of PI3K/Akt with LY294002. | veratric acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Our results suggest that veratric acid impedes the PI3K/Akt-mediated histone acetyl-transferase (HAT) activation and HDAC expression induced by LPS, thereby abrogating iNOS expression. | veratric acid | thymoma viral proto-oncogene 1 | Mus musculus |