Title : Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via β-catenin signaling.

Pub. Date : 2014

PMID : 25349993






1 Functional Relationships(s)
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1 Stable overexpression of PODX in LN-229 and U-118 MG human GBM cells increased the soluble/intracellular beta-cat level, TOPflash luciferase reporter activity, the mRNA levels of beta-cat signaling target genes, matrix metalloproteinase 9 (MMP9) expression/activity, and cell invasion and proliferation, which was abolished by selective p38 mitogen-activated protein kinase (MAPK) inhibitor PD169316 and selective beta-cat signaling inhibitor CCT031374. cct031374 podocalyxin like Homo sapiens