Pub. Date : 2014 Dec
PMID : 25349307
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. | alectinib | ret proto-oncogene | Homo sapiens |
2 | We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. | alectinib | ret proto-oncogene | Homo sapiens |
3 | We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. | alectinib | ret proto-oncogene | Homo sapiens |
4 | We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. | alectinib | ret proto-oncogene | Homo sapiens |
5 | In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. | alectinib | ret proto-oncogene | Homo sapiens |
6 | In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. | alectinib | ret proto-oncogene | Homo sapiens |
7 | In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. | alectinib | ret proto-oncogene | Homo sapiens |
8 | Our results suggest that alectinib is effective against RET fusion-positive tumors. | alectinib | ret proto-oncogene | Homo sapiens |
9 | Thus, alectinib might be a therapeutic option for patients with RET fusion-positive NSCLC. | alectinib | ret proto-oncogene | Homo sapiens |