Title : Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

Pub. Date : 2014 Dec

PMID : 25349307






9 Functional Relationships(s)
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1 Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. alectinib ret proto-oncogene Homo sapiens
2 We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. alectinib ret proto-oncogene Homo sapiens
3 We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. alectinib ret proto-oncogene Homo sapiens
4 We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. alectinib ret proto-oncogene Homo sapiens
5 In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. alectinib ret proto-oncogene Homo sapiens
6 In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. alectinib ret proto-oncogene Homo sapiens
7 In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. alectinib ret proto-oncogene Homo sapiens
8 Our results suggest that alectinib is effective against RET fusion-positive tumors. alectinib ret proto-oncogene Homo sapiens
9 Thus, alectinib might be a therapeutic option for patients with RET fusion-positive NSCLC. alectinib ret proto-oncogene Homo sapiens