Title : Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells.

Pub. Date : 2014

PMID : 25343516






2 Functional Relationships(s)
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1 Catalytic activity of CYP3A4/5 towards two prototypic substrates of CYP3A enzymes, testosterone and midazolam, was determined in presence of both (+)-ketoconazole and (-)-ketoconazole in human liver microsomes. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Catalytic activity of CYP3A4/5 towards two prototypic substrates of CYP3A enzymes, testosterone and midazolam, was determined in presence of both (+)-ketoconazole and (-)-ketoconazole in human liver microsomes. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens