Title : Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models.

Pub. Date : 2014

PMID : 25342886






2 Functional Relationships(s)
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1 We found that indole and NC001-8 up-regulated chaperone expression to reduce polyQ aggregation in neuronal differentiated TBP/Q79 cells. polyglutamine down-regulator of transcription 1 Homo sapiens
2 Our results demonstrate how indole and derivative NC001-8 reduce polyQ aggregation to support their therapeutic potentials in SCA17 treatment. polyglutamine down-regulator of transcription 1 Homo sapiens