Title : A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met.

Pub. Date : 2014 Oct 24

PMID : 25341359






3 Functional Relationships(s)
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1 Indeed, decreasing the cytosolic pH either with nigericin, an Na(+)/H(+) exchanger or pH 6.5 KRB buffer significantly increased the level of nuclear c-Met and the interaction of the c-Met fragment with importin beta, indicating that low pH itself enhanced nuclear translocation. Nigericin MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 Indeed, decreasing the cytosolic pH either with nigericin, an Na(+)/H(+) exchanger or pH 6.5 KRB buffer significantly increased the level of nuclear c-Met and the interaction of the c-Met fragment with importin beta, indicating that low pH itself enhanced nuclear translocation. Nigericin MET proto-oncogene, receptor tyrosine kinase Homo sapiens
3 Consistent with this, nigericin treatment also increased the nuclear level of endogenous c-Met in HeLa cells. Nigericin MET proto-oncogene, receptor tyrosine kinase Homo sapiens