Title : The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.

Pub. Date : 2014 Nov 4

PMID : 25331903






1 Functional Relationships(s)
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1 Previously, using transfected cell studies, we observed that although DAT Val559 displays normal total and surface DAT protein levels, and normal DA recognition and uptake, the variant transporter exhibits anomalous DA efflux (ADE) and lacks capacity for amphetamine (AMPH)-stimulated DA release. Amphetamine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus