Title : Differential effect of inhibitors of oligosaccharide processing on the secretion of thyrotropin from dispersed rodent pituitary cells.

Pub. Date : 1989 Dec 15

PMID : 2532008






1 Functional Relationships(s)
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1 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin, both inhibitors of glucosidases I and II, decreased intracellular TSH (to 60-76% of control) and secreted TSH (to 60-63% of control) after a 1-hour incubation (pulse) with [35S]methionine and an 8-hour incubation (chase) in isotope-free media. Thyrotropin mannosyl-oligosaccharide glucosidase Homo sapiens