Title : Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

Pub. Date : 2014 Dec 1

PMID : 25320009






1 Functional Relationships(s)
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1 PKM2 silencing decreased PK activity, intracellular lactate levels, and conversion of pyruvate to lactate in the same manner as TMZ, and Chk1 silencing blocked the TMZ-induced decrease in PKM2 expression. Pyruvic Acid pyruvate kinase M1/2 Homo sapiens