Title : Structure and ligand-based design of mTOR and PI3-kinase inhibitors leading to the clinical candidates VS-5584 (SB2343) and SB2602.

Pub. Date : 2014 Nov 24

PMID : 25317974






1 Functional Relationships(s)
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1 Compounds with a variety of headgroups were docked into the PI3Kalpha and mTOR ATP-binding sites, and aminopyrimidine and aminopyrazine were found to make excellent phenol replacements. 2-aminopyrimidine mechanistic target of rapamycin kinase Homo sapiens