Title : Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells.

Pub. Date : 2014 Dec 15

PMID : 25316568






4 Functional Relationships(s)
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1 Simvastatin induces NFkappaB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. Simvastatin activating transcription factor 2 Homo sapiens
2 Meanwhile, simvastatin induced JNK-mediated c-Jun and ATF-2 activation. Simvastatin activating transcription factor 2 Homo sapiens
3 Simvastatin enhanced the binding of c-Jun/ATF-2 with the MMP-2 promoter. Simvastatin activating transcription factor 2 Homo sapiens
4 Taken together, our data indicate that simvastatin-induced p65 instability leads to MMP-9 down-regulation in leukemia cells, while simvastatin-induced JNK1/c-Jun/ATF-2 activation maintains the MMP-2 expression underlying p65 down-regulation. Simvastatin activating transcription factor 2 Homo sapiens