Pub. Date : 2014 Dec 15
PMID : 25316568
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin induces NFkappaB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 2 | Simvastatin induces NFkappaB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 3 | The aim of the present study was to explore the signaling pathways associated with the effect of simvastatin on matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia K562 cells. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 4 | In sharp contrast to its insignificant effect on MMP-2, simvastatin down-regulated MMP-9 protein expression and mRNA levels in K562 cells. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 5 | Over-expression of Pin1 suppressed simvastatin-induced MMP-9 down-regulation. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 6 | Simvastatin treatment also suppressed MMP-9 but not MMP-2 expression in human leukemia U937 and KU812 cells. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |
| 7 | Taken together, our data indicate that simvastatin-induced p65 instability leads to MMP-9 down-regulation in leukemia cells, while simvastatin-induced JNK1/c-Jun/ATF-2 activation maintains the MMP-2 expression underlying p65 down-regulation. | Simvastatin | matrix metallopeptidase 9 | Homo sapiens |