Pub. Date : 2014 Dec
PMID : 25311433
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to investigate whether a novel compound derived from diterpene triepoxide (Minnelide ) can reactivate wild-type p53 function in HPV-positive HNSCC. | 14-O-phosphonooxymethyltriptolide disodium salt | tumor protein p53 | Homo sapiens |
| 2 | RESULTS: In HPV-positive HNSCC, Minnelide reactivated p53 by suppressing E6 oncoprotein. | 14-O-phosphonooxymethyltriptolide disodium salt | tumor protein p53 | Homo sapiens |
| 3 | In 2 preclinical HNSCC animal models (a subcutaneous xenograft model and a patient-derived tumor xenograft model), Minnelide reactivated p53 function and significantly decreased tumor progression and tumor volume. | 14-O-phosphonooxymethyltriptolide disodium salt | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSION: Triptolide and Minnelide caused cell death in vitro and in vivo in HPV-positive HNSCC by reactivating wild-type p53 and thus inducing apoptosis. | 14-O-phosphonooxymethyltriptolide disodium salt | tumor protein p53 | Homo sapiens |