Title : From pathways to targets: understanding the mechanisms behind polyglutamine disease.

Pub. Date : 2014

PMID : 25309920






1 Functional Relationships(s)
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1 The history of polyglutamine diseases dates back approximately 20 years to the discovery of a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of similar expansion mutations in Huntington"s disease, SCA1, DRPLA, and the other spinocerebellar ataxias. polyglutamine ataxin 1 Homo sapiens