Pub. Date : 2015 Jan
PMID : 25308201
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased CD8 T-cell granzyme B in COPD is suppressed by treatment with low-dose azithromycin. | Azithromycin | granzyme B | Homo sapiens |
| 2 | We previously showed that low-dose azithromycin reduced airways inflammation in COPD subjects and we hypothesized that it would also reduce granzyme B production by CD8 T cells. | Azithromycin | granzyme B | Homo sapiens |
| 3 | RESULTS: T-cell granzyme B production in both airway and intra-epithelial compartments was reduced in COPD patients following 12 weeks of azithromycin treatment, with no significant effect in blood. | Azithromycin | granzyme B | Homo sapiens |
| 4 | Both azithromycin and n-acetyl cysteine suppressed CD4 T-cell granzyme B production, but only azithromycin was effective at reducing CD8+ T-cell granzyme B production in vitro. | Azithromycin | granzyme B | Homo sapiens |
| 5 | Both azithromycin and n-acetyl cysteine suppressed CD4 T-cell granzyme B production, but only azithromycin was effective at reducing CD8+ T-cell granzyme B production in vitro. | Azithromycin | granzyme B | Homo sapiens |