Pub. Date : 2015 Dec
PMID : 25307746
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone, a PPARgamma agonist, inhibits growth and invasion of human hepatocellular carcinoma via blockade of the rage signaling. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |
| 2 | We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti-tumor process. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |
| 3 | We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti-tumor process. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |
| 4 | Moreover, PGZ inhibited proliferative activity and invasive potential, and induced apoptosis and cell cycle arrest in HCC cells resulting in increased expression of PPARgamma and decreased expression of RAGE, NF-kappaB, HMGB1, p38MAPK, Ki-67, MMP-2, and CyclinD1. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |
| 5 | Furthermore, knockdown of RAGE or NF-kappaB by siRNA effectively suppressed cell proliferation and invasion, and mediated the inhibitory effects of PGZ in HCC cells. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |
| 6 | In addition, PGZ as a PPARgamma agonist may inhibit growth and invasion of HCC cells via blockade of the RAGE signaling. | Pioglitazone | advanced glycosylation end-product specific receptor | Homo sapiens |