Title : Strategic Role of Nuclear Inositide Signalling in Myelodysplastic Syndromes Therapy.

Pub. Date : 2014 Oct 13

PMID : 25307310






1 Functional Relationships(s)
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1 In the last few years, a role for nuclear inositide signalling as a therapeutic target in MDS has been disclosed, in that PI-PLCβ1 increase is associated with azacitidine responsiveness, even when this drug is used in combination with other agents, and Akt is specifically activated in MDS at higher risk of AML evolution. Azacitidine phospholipase C beta 1 Homo sapiens