Title : In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts.

Pub. Date : 2014 Dec

PMID : 25304236






1 Functional Relationships(s)
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1 Although argininosuccinate synthase induction could not be induced in vitro, a drug targeting pathway previously demonstrated to be associated with Ser62 cMyc phosphorylation - U0126 - in combination with CoArgIPEG demonstrated an in-vitro synergistic response (combination indices 0.13+-0.10 and 0.14+-0.10 with or without citrulline, respectively). U 0126 MYC proto-oncogene, bHLH transcription factor Homo sapiens