Title : Permanent culture of macrophages at physiological oxygen attenuates the antioxidant and immunomodulatory properties of dimethyl fumarate.

Pub. Date : 2015 May

PMID : 25303683






2 Functional Relationships(s)
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1 We hypothesized that O2 tension influences the redox state and the immunomodulatory responses of inflammatory cells to dimethyl fumarate (DMF), an activator of the nuclear factor Nrf2 that controls antioxidant genes expression. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
2 We hypothesized that O2 tension influences the redox state and the immunomodulatory responses of inflammatory cells to dimethyl fumarate (DMF), an activator of the nuclear factor Nrf2 that controls antioxidant genes expression. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens