Title : c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells.

Pub. Date : 2014 Oct 9

PMID : 25299780






3 Functional Relationships(s)
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1 Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens