Title : Scaffold hopping approach on the route to selective tankyrase inhibitors.

Pub. Date : 2014 Nov 24

PMID : 25299683






1 Functional Relationships(s)
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1 Through pharmacophore screening of a compounds collection from the SPECS database, the methoxy[l]benzothieno[2,3-c]quinolin-6(5H)-one scaffold was identified as nicotinamide mimetic able to inhibit tankyrase activity at low micromolar concentration. Niacinamide tankyrase Homo sapiens