Title : Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3.

Pub. Date : 2014

PMID : 25298788






6 Functional Relationships(s)
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1 Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens
2 This study investigates the role of the intracellular adenosine transporter equilibrative nucleoside transporter 3 (ENT3) in stimulated release of the gliotransmitter adenosine triphosphate (ATP) from astrocytes. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens
3 This study investigates the role of the intracellular adenosine transporter equilibrative nucleoside transporter 3 (ENT3) in stimulated release of the gliotransmitter adenosine triphosphate (ATP) from astrocytes. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens
4 A recent demonstration that the mainly intracellular nucleoside transporter ENT3 shows much higher expression in freshly isolated astrocytes than in a corresponding neuronal preparation leads to the suggestion that it was important for the synthesis of gliotransmitter ATP from adenosine. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens
5 It showed that the stimulated ATP release was abolished by downregulation of ENT3 with small interfering RNA (siRNA), regardless of the stimulus. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens
6 In neurons, this transporter carries ATP into synaptic vesicles, but in astrocytes, its expression is pronounced only in immature cells and shows a rapid decline during the first 3 postnatal weeks so that it has almost disappeared at the end of the third week in well-differentiated astrocytes, where its role has probably been taken over by ENT3. Adenosine Triphosphate solute carrier family 29 member 3 Homo sapiens