Title : Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.

Pub. Date : 2014 Oct 28

PMID : 25298532






2 Functional Relationships(s)
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1 Our structure of CD1c with the mycobacterial phosphomycoketide (PM) shows similarities to that of CD1c-mannosyl-beta1-phosphomycoketide in that the A" pocket accommodates the mycoketide alkyl chain; however, the phosphate head-group of PM is shifted ~6 A in relation to that of mannosyl-beta1-PM. phosphomycoketide CD1c molecule Homo sapiens
2 Our structure of CD1c with the mycobacterial phosphomycoketide (PM) shows similarities to that of CD1c-mannosyl-beta1-phosphomycoketide in that the A" pocket accommodates the mycoketide alkyl chain; however, the phosphate head-group of PM is shifted ~6 A in relation to that of mannosyl-beta1-PM. phosphomycoketide CD1c molecule Homo sapiens