Title : Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

Pub. Date : 2014 Nov

PMID : 25295542






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 IL-1beta cleavage and secretion were impaired in HO-1-deficient macrophages, and CO-dependent processing of IL-1beta required the presence of bacteria-derived ATP. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 The ATP then bound to macrophage nucleotide P2 receptors, resulting in activation of the NALP3/IL-1beta inflammasome to amplify bacterial phagocytosis by macrophages. Adenosine Triphosphate interleukin 1 beta Mus musculus