Title : Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

Pub. Date : 1989 Oct

PMID : 2529540






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Loss of MYC seems to be associated with granulocytic differentiation because the time course of its loss was similar to that of appearance of nitroblue tetrazolium-positive cells, mature granulocytes, and its loss was not observed on differentiation of HL-60 cells into macrophages induced by phorbol 12-myristate 13-acetate or teleocidin. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens