Pub. Date : 2014 Dec
PMID : 25293877
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently showed that apo-10"-lycopenoic acid, a lycopene metabolite generated by beta-carotene-9",10"-oxygenase (BCO2), inhibited carcinogen-initiated, high-fat diet (HFD)-promoted liver inflammation, and hepatic tumorigenesis development. | Lycopene | beta-carotene oxygenase 2 | Mus musculus |
| 2 | In contrast, the protective effects of lycopene in BCO2-KO but not in wild-type mice were associated with reduced hepatic endoplasmic reticulum stress-mediated unfolded protein response (ER(UPR)), through decreasing ER(UPR)-mediated protein kinase RNA-activated like kinase-eukaryotic initiation factor 2alpha activation, and inositol requiring 1alpha-X-box-binding protein 1 signaling. | Lycopene | beta-carotene oxygenase 2 | Mus musculus |
| 3 | Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels. | Lycopene | beta-carotene oxygenase 2 | Mus musculus |
| 4 | These results provided novel experimental evidence that dietary lycopene can prevent HFD-promoted HCC incidence and multiplicity in mice, and may elicit different mechanisms depending on BCO2 expression. | Lycopene | beta-carotene oxygenase 2 | Mus musculus |