Pub. Date : 2014 Oct 7
PMID : 25289898
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 stimulates beta1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-kappaB pathway. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | 17-PT-PGE2 treatment induced PKC and NF-kappaB activation; PKC and NF-kappaB inhibitors suppressed 17-PT-PGE2-mediated beta1-integrin expression. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | 17-PT-PGE2 treatment induced PKC and NF-kappaB activation; PKC and NF-kappaB inhibitors suppressed 17-PT-PGE2-mediated beta1-integrin expression. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Targeting PGE2/EP1/PKC/NF-kappaB/FoxC2/beta1-integrin pathway may represent a new therapeutic strategy for the prevention and treatment of this cancer. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |