Title : Nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia.

Pub. Date : 2014 Dec 5

PMID : 25280787






1 Functional Relationships(s)
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1 H2O2 at toxic levels activated p38 mitogen-activated protein kinases (MAPK) and p53 pathways and increased DNA double strand breaks (DSBs) in microglia, whereas the rescue exerted by sublytic SNAP against toxic H2O2 occurred via the activation of both Akt and extracellular-signal-regulated kinase (ERK) cascades and decreased DNA DSBs. Hydrogen Peroxide mitogen activated protein kinase 14 Rattus norvegicus