Title : Impact of mast cells on multiple sclerosis: inhibitory effect of natalizumab.

Pub. Date : 2014 Jul-Sep

PMID : 25280024






1 Functional Relationships(s)
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1 Mast cells mature under local tissue microenvironmental factors and are necessary for the development of allergic reactions, through crosslinking of their surface receptors for IgE (FcepsilonRI), leading to degranulation and the release of vasoactive, pro-inflammatory and nociceptive mediators that include histamine, pro-inflammatory and anti-inflammatory cytokines and proteolytic enzymes. Histamine Fc epsilon receptor Ia Homo sapiens