Title : A novel ACE2 activator reduces monocrotaline-induced pulmonary hypertension by suppressing the JAK/STAT and TGF-β cascades with restored caveolin-1 expression.

Pub. Date : 2015 Feb

PMID : 25275723






3 Functional Relationships(s)
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1 Here we identified a novel ACE2 activator and investigated how the compound reduced monocrotaline (MCT)-induced PH. Monocrotaline angiotensin I converting enzyme 2 Rattus norvegicus
2 Here we identified a novel ACE2 activator and investigated how the compound reduced monocrotaline (MCT)-induced PH. Monocrotaline angiotensin I converting enzyme 2 Rattus norvegicus
3 Interestingly, NCP-2454 increased the relative expression of ACE2 and MAS mRNA in lung tissue, especially in MCT-treated rats. Monocrotaline angiotensin I converting enzyme 2 Rattus norvegicus