Title : Network dynamics determine the autocrine and paracrine signaling functions of TNF.

Pub. Date : 2014 Oct 1

PMID : 25274725






1 Functional Relationships(s)
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1 Contrary to expectation, we predicted and then experimentally confirmed that in response to lipopolysaccaride, TNF does not have an autocrine function in amplifying the NFkappaB response, although it plays a potent paracrine role in neighboring cells. lipopolysaccaride tumor necrosis factor Homo sapiens